Definition of Therapeutic index
The therapeutic index is a measure of drug selectivity, and analogous index numbers are frequently computed to measure selectivity that does not involve lethal effects. For example, to measure the selectivity of a drug potentially useful in the treatment of epilepsy, the ED50 for producing ataxia in mice might be compared to the ED50 for abolishing electrically-induced convulsions in mice.
Cf. Median Effective Dose, Selectivity, Standardized Safety Margin, Clinical Therapeutic Index
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