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Definition of Therapeutic index

Therapeutic index Definition from Medicine Dictionaries & Glossaries
TOXICOLOGY
The ratio of the dose needed to produce the desired therapeutic response to the dose producing toxicity.
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Terms and symbols used in pharmacology
A number, LD50/ED50, which is a measure of the approximate "safety factor" for a drug; a drug with a high index can presumably be administered with greater safety than one with a low index. The therapeutic index is ordinarily calculated from data obtained from experiments with animals. As in comparing ED50s from two different drugs, the comparison of the LD50 and ED50 (therapeutic index) is most meaningful when the dose-effect curves from which the ED50 and LD50 are inferred are parallel.

The therapeutic index is a measure of drug selectivity, and analogous index numbers are frequently computed to measure selectivity that does not involve lethal effects. For example, to measure the selectivity of a drug potentially useful in the treatment of epilepsy, the ED50 for producing ataxia in mice might be compared to the ED50 for abolishing electrically-induced convulsions in mice.

Cf. Median Effective Dose, Selectivity, Standardized Safety Margin, Clinical Therapeutic Index

Therapeutic index Definition from Society & Culture Dictionaries & Glossaries
EPA Terms of Environment
The ratio of the dose required to produce toxic or lethal effects to the dose required to produce nonadverse or therapeutic response.
Provided as a public service by the U.S. Environmental Protection Agency
Environmental Engineering (English ver.)
The ratio of the dose required to produce toxic or lethal effects to the dose required to produce nonadverse or therapeutic response.
Therapeutic index Definition from Encyclopedia Dictionaries & Glossaries
Wikipedia English - The Free Encyclopedia
The therapeutic index (also known as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes death (in animal studies) or toxicity (in human studies).

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