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Fr901228 Definition from Medicine Dictionaries & Glossaries
A substance being studied in the treatment of cancer. FR901228 is a type of depsipeptide and belongs to the family of drugs called histone deacetylase inhibitors.
A Service of the National Cancer Institute.Fr901228 Definition from Encyclopedia Dictionaries & Glossaries
Romidepsin (INN, trade name Istodax), codenamed FK228 and FR901228, is an anticancer agent undergoing clinical trials as a treatment for cutaneous T-cell lymphoma (CTCL), peripheral T-cell lymphoma, and a variety of other cancers. Romidepsin is a natural product obtained from the bacteria Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases and inducing apoptosis. It is sometimes referred to as depsipeptide, after the class of molecules to which it belongs.
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