a direct marker of disease progression, e.g., disease symptoms or death. The effectiveness of drug therapies is often determined by observing the clinical endpoints that develop over time in patients undergoing experimental treatment. Contrast with surrogate marker.
Glossary of HIV/AIDS-Related Terms
A category of data used to compare the outcome in different arms of a clinical trial. Common endpoints are severe toxicity, disease progression, or -- especially in HIV disease -- surrogate markers, such as CD4 count; sometimes death is used as an endpoint. The term is confusing because it often incorrectly implies that patients in a study are no longer followed after they experience an endpoint. This is obviously true where the event is death, but need not be so for nonfatal events. In fact, the design of the trial may require continued treatment and follow-up of patients over the entire course of the trial, regardless of the number of nonfatal "endpoints" observed.
HIV Vaccine Glossary
the results of an intervention such as vaccination compared among different study groups in a clinical trial. In early vaccine trials, common endpoints are safety and specific types and intensities of immune responses (neutralizing antibodies, CTL responses).