Say it 1. A loss of chemical function, usually due to some heat or chemically-induced structural change. For example, heating a protein causes it to lose its three dimensional form and it no longer functions correctly.
Denaturation Definition from Encyclopedia Dictionaries & Glossaries
Hepatitis Central (TM) Liver Disease Medical Glossary
Reversible or irreversible loss of function in proteins and nucleic acids resulting from loss of higher order secondary, tertiary or quaternary structure) produced by nonphysiological conditions of pH, temperature, salt or organic solvents