azacitidine
An anticancer drug that belongs to the family of drugs called antimetabolites. | ||||
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Azacitidine Definition from Encyclopedia Dictionaries & Glossaries
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5-Azacytidine
5-Azacytidine is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of 5-azacytidine incorporate it into DNA during replication and RNA during transcription. The incorporation of 5-azacytidine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence, affecting the way that cell regulation proteins are able to bind to the DNA/RNA substrate. Inhibition of DNA occurs through the formation of stable complexes between the molecule and with DNA methyltransferases, thereby saturating the cells methylation machinery.
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