ancestim
[an-SESS-tim] A drug that is being studied for its ability to increase the number of stem cells in the blood. It belongs to the family of drugs called hematopoietic cell growth factors. Also called stem cell factor (SCF) and Stemgen. | ||||
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Ancestim Definition from Encyclopedia Dictionaries & Glossaries
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Ancestim
Ancestim is a recombinant methionyl human stem cell factor, commonly known by the name StemGen.
It is a 166 amino acid protein produced by Ecoli bacteria into which a gene has been inserted for soluble human stem cell factor. It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in Ecoli. Because Ancestim is produced in Ecoli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised powder for reconstitution and administration as a subcutaneous (SC) injection.
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