amsacrine
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. | ||||
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Amsacrine definition was found in categories: Medicine(1) Encyclopedia(1)
Amsacrine Definition from Medicine Dictionaries & Glossaries
Amsacrine Definition from Encyclopedia Dictionaries & Glossaries
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Amsacrine
Amsacrine is an antineoplastic agent. Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors.
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