aminoglutethimide
[a-MEE-no-gloo-TETH-ih-mide] An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors that need sex hormones to grow. | ||||
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Aminoglutethimide Definition from Medicine Dictionaries & Glossaries
Aminoglutethimide Definition from Encyclopedia Dictionaries & Glossaries
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Aminoglutethimide
Aminoglutethimide is a first generation aromatase inhibitor used in the treatment of breast cancer and Cushing's syndrome. It blocks the synthesis of estrogen through inhibition of the aromatase enzyme. Aminoglutethimide also inhibits many of the enzymes involved in the generation of corticosteroids. It blocks the conversion of cholesterol to pregnenolone and inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.
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