TNF
theater nuclear force | ||||
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TNF definition was found in categories: Language, Idioms & Slang(2) Medicine(3) Government(1) Computer & Internet(1) Encyclopedia(1)
TNF Definition from Language, Idioms & Slang Dictionaries & Glossaries
| WordNet 2.0 |
TNF
Noun
1. a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
(synonym) tumor necrosis factor, tumour necrosis factor
(hypernym) cytokine
Noun
1. a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
(synonym) tumor necrosis factor, tumour necrosis factor
(hypernym) cytokine
| hEnglish - advanced version |
tnf
tnf
n : a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis) [syn: tumor necrosis factor, tumour necrosis factor , tnf]
tnf
n : a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis) [syn: tumor necrosis factor, tumour necrosis factor , tnf]
TNF Definition from Medicine Dictionaries & Glossaries
| NCI Dictionary of Cancer Terms |
TNF
Tumor necrosis factor. A type of biological response modifier (a substance that can improve the body's natural response to disease).
Tumor necrosis factor. A type of biological response modifier (a substance that can improve the body's natural response to disease).
| Aids Glossary |
tnf
abbreviation, tumor necrosis factor. a naturally occuring protein. TNF destroys cancer cells, but is suspected as being a co-factor in HIV replication.
abbreviation, tumor necrosis factor. a naturally occuring protein. TNF destroys cancer cells, but is suspected as being a co-factor in HIV replication.
tumor necrosis factor (tnf¸ cachectin)
a cytokine, produced by activated monocytes and macrophages, that can destroy tumors. When
chronically elevated (as may occur in HIV disease), TNF-alpha may lead to fever, anorexia, hypermetabolism and wasting. TNF-alpha may block the production of enzymes that digest fats, leading to the breakdown of muscle tissue. In laboratory tests TNF-alpha has been shown to stimulate HIV replication. Some drugs (e.g., thalidomide, ketotifen) reduce TNF-alpha levels. TNF-beta is released by CD4 and CD8 T-cells when stimulated by an antigen. VERIFY TNF-BETA.
| Glossary of HIV/AIDS-Related Terms |
TUMOR NECROSIS FACTOR
A cytokine<!-- (see) -->, produced by macrophages<!-- (see) -->, which helps activate T cells<!-- (see) -->. It also may stimulate HIV activity. TNF levels are very high in persons with HIV, and the molecule is suspected to play a part in HIV-related wasting, neuropathy, and dementia (see entries for these terms). TNF triggers a biochemical pathway that leads to the programmed form of cell suicide known as apoptosis<!-- (see) -->. It also activates a key molecule that can block this very pathway, and so set up a delicate life-death balance within the cell.
A cytokine<!-- (see) -->, produced by macrophages<!-- (see) -->, which helps activate T cells<!-- (see) -->. It also may stimulate HIV activity. TNF levels are very high in persons with HIV, and the molecule is suspected to play a part in HIV-related wasting, neuropathy, and dementia (see entries for these terms). TNF triggers a biochemical pathway that leads to the programmed form of cell suicide known as apoptosis<!-- (see) -->. It also activates a key molecule that can block this very pathway, and so set up a delicate life-death balance within the cell.
TNF Definition from Government Dictionaries & Glossaries
| NATO Acronyms |
TNF
Theatre Nuclear Forces
Theatre Nuclear Forces
TNF Definition from Computer & Internet Dictionaries & Glossaries
| Computer Abbreviations v1.5 |
TNF
Transport Neutral Encapsulation Format File
Transport Neutral Encapsulation Format File
TNF Definition from Encyclopedia Dictionaries & Glossaries
| Wikipedia English - The Free Encyclopedia |
Tumor necrosis factors
Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family which can cause apoptosis.
Tumor necrosis factor-alpha is the most well known member of this class, and sometimes the term "tumor necrosis factor" is used to refer to this specific form.
TNF acts via the TNF Receptor (TNF-R) and is part of the extrinsic pathway for triggering apoptosis. TNF-R is associated with procaspases through adapter proteins (FADD, TRADD, etc.) that can cleave other inactive procaspes and trigger the caspase cascade, irreversibly committing the cell to apoptosis.
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