Reed-Sternberg cell
A type of cell that appears in people with Hodgkin's disease. The number of these cells increases as the disease advances. | ||||
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Reed-Sternberg cell Definition from Medicine Dictionaries & Glossaries
| Dictionary of Medicine (Shahram) |
Reed-Sternberg cell
A type of cell that appears in patients with Hodgkin's disease. The number of these cells increases as the disease advances.
A type of cell that appears in patients with Hodgkin's disease. The number of these cells increases as the disease advances.
Reed-Sternberg cell Definition from Encyclopedia Dictionaries & Glossaries
| Wikipedia English - The Free Encyclopedia |
Reed-Sternberg cell
Reed-Sternberg cells (Lacunar Histiocytes for certain types) are distinctive giant cells found on light microscopy in biopsies from individuals with Hodgkin's lymphoma (aka Hodgkin's disease; a type of lymphoma), and certain other disorders. They are derived from B lymphocytes.
They are named after Dorothy Reed Mendenhall (1874-1964) and Carl Sternberg (1872-1935), who provided the first definitive microscopic descriptions of Hodgkin's disease (Reed, 1902; Sternberg, 1898).
Reed-Sternberg cells are large and are either multinucleated or have a bilobed nucleus (thus resembling an "owl's eye" appearance) with prominent eosinophilic inclusion-like nucleoli. Reed-Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is not pathognomonic for the diagnosis of classical Hodgkin's lymphoma. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and rarely non-Hodgkin lymphomas.
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