R-flurbiprofen
A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). | ||||
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R-flurbiprofen Definition from Encyclopedia Dictionaries & Glossaries
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R-flurbiprofen
R-flurbiprofen is the single enantiomer of the racemate NSAID flurbiprofen. This compound is currently in clinical trials for the treatment of Alzheimer's disease, and has been assigned the trade name tarenflurbil. At therapeutic concentrations, this molecule lacks anti-inflammatory activity, and does not inhibit either cyclooxygenase 1 (COX-1) or cyclooxygenase 2 (COX-2) enzymes. Only the S-enantiomers of arylpropionic acid NSAIDS can potently inhibit COX, whereas the R-enantiomers exert almost no COX activity. R-flurbiprofen is inefficiently converted into S-flurbiprofen, with 1.5% of the R-enantiomer undergoing bioinversion to the S-form.
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