Alteplase
A protein that is made by the body and that helps dissolve blood clots. It can also be made in the laboratory and is used in the treatment of heart attack and stroke. It is also being studied in the treatment of cancer. Alteplase belongs to the family of drugs called systemic thrombolytic agents. Also called tissue plasminogen activator (tPA), recombinant tissue plasminogen activator (r-tPA), and Activase. | ||||
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Alteplase Definition from Encyclopedia Dictionaries & Glossaries
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Tissue plasminogen activator
Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin.
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